Proteomics

Dataset Information

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Crosstalk between pentraxin-3 and humoral pattern-recognition receptors plays an essential role in immunomodulation against Aspergillus fumigatus


ABSTRACT: The study investigated the interaction between pentraxin-3 (PTX3), a soluble pattern-recognition receptor, and the fungal pathogen Aspergillus fumigatus. The aim was to identify the ligands for PTX3 and the impact of PTX3 on the immune response. A. fumigatus spores, hyphae or cell wall components were incubated with PTX3, human serum and others humoral factors and their interaction was studied by immunofluorescence, flow cytometry and ELISA. Opsonizd conidia were co-incubated with human monocyte-derived macrophages (hMDM) and cytokine secretion was measured.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Neosartorya Fumigata (aspergillus Fumigatus)

SUBMITTER: Thomas Krüger  

LAB HEAD: Axel A. Brakhage

PROVIDER: PXD043546 | Pride | 2024-08-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
1-a.raw Raw
1-b.raw Raw
1-c.raw Raw
1.fasta Fasta
1.mgf Mgf
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