Dataset Information

Hydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation

ABSTRACT: Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome. Blood samples, medication and bioelectrical impedance analysis (BIA) details were collected from 131 geriatric patients (77 women, 54 men). Based on an evaluation by Bioelectrical Impedance Vector Analyses (BIVA) of this cohort, for each hydration status (dehydrated, hyperhydrated and control), five appropriate blood serum samples for both male and female were analyzed by LC-MS. Overall, 262 proteins for female patients and 293 proteins for male patients could be quantified. 38 proteins had significantly different abundance, showing that hydration status does indeed affect the serum proteome. Protein enrichment analysis of the affected proteins revealed “Wound Healing” and “Keratinization” as the two main biological processes being dysregulated. Especially, proteins involved in clot formation are affected by hydration status.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Dehydration

SUBMITTER: Johannes Schmidt

LAB HEAD: Johannes Schmidt

PROVIDER: PXD043728 | Pride | 2023-10-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20210611_CO_0966JoSc_SetD_R138.raw	Raw
	20210611_CO_0966JoSc_SetD_R139.raw	Raw
	20210611_CO_0966JoSc_SetD_R140.raw	Raw
	20210611_CO_0966JoSc_SetD_R141.raw	Raw
	20210611_CO_0966JoSc_SetD_R142.raw	Raw

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Publications

Hydration Status of Geriatric Patients Is Associated with Changes in Plasma Proteome, Especially in Proteins Involved in Coagulation.

Hoen Laura L Pfeffer Daniel D Schmidt Johannes R JR Kraft Johannes J Hildebrand Janosch J Kalkhof Stefan S

Nutrients 20230830 17

Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome. Blood samples, medication, and bioelectrical impedance analysis (BIA) details were collected from 131 geriatric patients (77 women and 54 men aged 81.1 ± 7.2 years). Based on an evaluation by Bioelectrical Impedance Vector Analyses (BIVAs) of this cohort, for ...[more]

PMID: 37686821

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