Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (mouse)
DISEASE(S): Melanoma
SUBMITTER: Alejandro Leyva
LAB HEAD: Rosario Durán
PROVIDER: PXD043779 | Pride | 2024-01-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
20190923_Mus_musculus.fasta | Fasta | |||
checksum.txt | Txt | |||
shMfn1_DMSO_1.raw | Raw | |||
shMfn1_DMSO_1.txt | Txt | |||
shMfn1_DMSO_1_1.raw | Raw |
Items per page: 1 - 5 of 38 |
Scientific reports 20240109 1
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and mitochondrial energy metabolism supports resistance to therapy in melanoma. In a previous report we showed that senescence, induced by the DNA methylating agent temozolomide, increased the level of fusion proteins mitofusin 1 and 2 in melanoma, and silencing ...[more]