Proteomics

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Proteomic analysis reveals the neurotoxic effects of chronic methamphetamine self-administration-induced cognitive impairments and the role of melatonin-enhanced restorative process during drug withdrawal.

ABSTRACT: , this study aimed to investigate the mechanisms underlying neuropathological processes related to cognitive impairment in mice chronically-treated with METH. In addition, the effective melatonin on recovery of neurological dysfunction and neurobehavioral deficits during METH withdrawal was also investigated. Cognitive function was evaluated in mice after chronic METH administration and METH withdrawal, and the effect of melatonin treatment during the withdrawal phase on cognitive function was also assessed. In addition, the profile of proteins related to mitochondrial and neurological functions in PFC was determined using proteomic and western blot analysis.

INSTRUMENT(S): compact

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Tanthai Polvat  

LAB HEAD: Tanthai Polvat

PROVIDER: PXD043828 | Pride | 2023-10-24

REPOSITORIES: Pride

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METH-01-rep1-SA-NT.d.rar Other
METH-01-rep1-SA-NT.dat Other
METH-01-rep1-SA-NT.mgf Mgf
METH-01-rep1-WD-NT.d.rar Other
METH-01-rep1-WD-NT.dat Other
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Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal.

Polvat Tanthai T   Prasertporn Tanya T   Na Nakorn Piyada P   Pannengpetch Supitcha S   Suwanjang Wilasinee W   Panmanee Jiraporn J   Ngampramuan Sukhonthar S   Cornish Jennifer L JL   Chetsawang Banthit B  

Journal of proteome research 20230907 10

Cognitive flexibility is a crucial ability in humans that can be affected by chronic methamphetamine (METH) addiction. The present study aimed to elucidate the mechanisms underlying cognitive impairment in mice chronically administered METH via an oral self-administration method. Further, the effect of melatonin treatment on recovery of METH-induced cognitive impairment was also investigated. Cognitive performance of the mice was assessed using an attentional set shift task (ASST), and possible  ...[more]

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