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Comparative analysis of the proteome of Th2 lymphocytes from WT or ASB2 KO mice

ABSTRACT: ASB2α is an E3 ubiquitin ligase which is upregulated during Th2 differentiation of naive CD4+ T lymphocyte, and which is known to trigger ubiquitylation and proteasomal degradation of filamins (FLN) a and b. Because E3 ubiquitin ligases often ubiquitylate several substrates, we used an unbiased and broad mass spectrometry approach to identify ASB2α substrates in Th2 lymphocytes generated from naïve CD4+ T lymphocytes of control or ASB2 KO mice.

INSTRUMENT(S): timsTOF SCP

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): T Cell, Cell Culture

SUBMITTER: Emmanuelle Mouton Barbosa

LAB HEAD: Odile Burley Schiltz

PROVIDER: PXD044062 | Pride | 2024-09-24

REPOSITORIES: Pride

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			Action	DRS
	KO1-NS-inj5uL_2932.d.zip	Other
	KO2-NS-inj5uL_2934.d.rar	Other
	KO3-NS-inj5uL_2936.d.rar	Other
	KO4-NS-inj5uL_2938.d.rar	Other
	KO5-NS-inj5uL_2940.d.rar	Other

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