Dataset Information

Investigating the mechanism(s) underlying tryptamine and phenethylamine inhibition on insulin signaling

ABSTRACT: To investigate the mechanism(s) underlying tryptamine inhibition on insulin signaling, we employed a phospho-proteomics approach to capture the molecular components that are significantly altered by tryptamine.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Fat Body

DISEASE(S): Disease Free

SUBMITTER: Lixiang Zhai

LAB HEAD: Lixiang Zhai

PROVIDER: PXD044161 | Pride | 2023-10-24

REPOSITORIES: Pride

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Publications

Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome.

Zhai Lixiang L Xiao Haitao H Lin Chengyuan C Wong Hoi Leong Xavier HLX Lam Yan Y YY Gong Mengxue M Wu Guojun G Ning Ziwan Z Huang Chunhua C Zhang Yijing Y Yang Chao C Luo Jingyuan J Zhang Lu L Zhao Ling L Zhang Chenhong C Lau Johnson Yiu-Nam JY Lu Aiping A Lau Lok-Ting LT Jia Wei W Zhao Liping L Bian Zhao-Xiang ZX

Nature communications 20230817 1

The incidence of metabolic syndrome is significantly higher in patients with irritable bowel syndrome (IBS), but the mechanisms involved remain unclear. Gut microbiota is causatively linked with the development of both metabolic dysfunctions and gastrointestinal disorders, thus gut dysbiosis in IBS may contribute to the development of metabolic syndrome. Here, we show that human gut bacterium Ruminococcus gnavus-derived tryptamine and phenethylamine play a pathogenic role in gut dysbiosis-induce ...[more]

PMID: 37591886

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			Action	DRS
	9802_.msf	Msf
	9802_FeNTA_1.raw	Raw
	9802_TiO2_1.raw	Raw
	Peptides.xlsx	Xlsx
	Proteins.xlsx	Xlsx