Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Kevin Sabath
LAB HEAD: Dr. Stefanie Jonas
PROVIDER: PXD044324 | Pride | 2024-07-31
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 14 |
Sabath Kevin K Qiu Chunhong C Jonas Stefanie S
Molecular cell 20240719 15
The modular Integrator complex is a transcription regulator that is essential for embryonic development. It attenuates coding gene expression via premature transcription termination and performs 3'-processing of non-coding RNAs. For both activities, Integrator requires endonuclease activity that is harbored by an RNA cleavage module consisting of INTS4-9-11. How correct assembly of Integrator modules is achieved remains unknown. Here, we show that BRAT1 and WDR73 are critical biogenesis factors ...[more]