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Catovirus naegleriensis (Naegleriavirus) shotgun LCMS/MS

ABSTRACT: Naegleriavirus virions purified from the amoeboflagellate Naegleriaclarki were analysed. The virus infects members of the genus Naegleriaincluding the infamous human pathogen Naegleria fowleri, the causativeagent of the rare but lethal disease primary amoebicmeningoencephalitis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Naegleria Fowleri

TISSUE(S): Cell Suspension Culture, Organism Or Virus Or Viroid

DISEASE(S): Primary Amebic Meningoencephalitis

SUBMITTER: Stefane Wienkoop

LAB HEAD: Stefanie Wienkoop

PROVIDER: PXD044853 | Pride | 2024-04-29

REPOSITORIES: Pride

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A giant virus infecting the amoeboflagellate Naegleria.

Arthofer Patrick P Panhölzl Florian F Delafont Vincent V Hay Alban A Reipert Siegfried S Cyran Norbert N Wienkoop Stefanie S Willemsen Anouk A Sifaoui Ines I Arberas-Jiménez Iñigo I Schulz Frederik F Lorenzo-Morales Jacob J Horn Matthias M

Nature communications 20240424 1

Giant viruses (Nucleocytoviricota) are significant lethality agents of various eukaryotic hosts. Although metagenomics indicates their ubiquitous distribution, available giant virus isolates are restricted to a very small number of protist and algal hosts. Here we report on the first viral isolate that replicates in the amoeboflagellate Naegleria. This genus comprises the notorious human pathogen Naegleria fowleri, the causative agent of the rare but fatal primary amoebic meningoencephalitis. We ...[more]

PMID: 38658525

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