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Competitive colonization of Akkermansia muciniphila clades by microbial extracellular vesicles through direct inhibition and immune stimulation

ABSTRACT: Akkermansia muciniphila, a candidate for next-generation probiotics, can be classified into several clades with distinct genomic divergence. However, the global distribution and population structure of clade-typed A. muciniphila remain poorly understood. Here, we report on the predominance of single A. muciniphila clades in humans globally. We found that the predominance of the A. muciniphila clade is dynamically regulated by the balance between inter-clade inhibitory and pre-occupancy effects. A. muciniphila clade II (AmII)-derived extracellular vesicles exhibited a unilateral inhibitory effect on the growth of AmI. Clade-specific IgA responses were induced by each clade. AmII clade-specific IgAs, also induced by extracellular vesicles, facilitate the competitive exclusion of AmI. Our findings help toward the development of personalized intervention strategies for A. muciniphila, considering a subject’s A. muciniphila type.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Akkermansia Muciniphila

TISSUE(S): Cell Culture

SUBMITTER: Moon-Gi Hong

LAB HEAD: Young-Do Nam

PROVIDER: PXD045095 | Pride | 2025-02-11

REPOSITORIES: pride

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			Action	DRS
	220531_hela_150.raw	Raw
	AMDK-19_ncbi.faa	Other
	AMDK-39_ncbi.faa	Other
	BAA-835_ncbi.faa	Other
	allPeptides.txt	Txt

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