Dataset Information

Proteomic Analysis Reveals Trilaciclib-Induced Senescence

ABSTRACT: Trilaciclib, a CDK4/6 inhibitor, was approved as a myeloprotective agent for extensive-stage small cell lung cancer in 2021. It achieves this by inducing a temporary cell cycle arrest in bone marrow cells. While it has been studied in various cancer types, its potential in haematological cancers remains unexplored. This research aimed to investigate the efficacy of trilaciclib in haematological cancers.

INSTRUMENT(S): Q Exactive HF, Bruker Daltonics timsTOF series

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture, T Cell, Monocyte, Leukocyte

DISEASE(S): Acute Leukemia,Lymphoma

SUBMITTER: Matthias Trost

LAB HEAD: Matthias Trost

PROVIDER: PXD045276 | Pride | 2024-06-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	FASTAProteinContamPrefix_HaoLab.fasta	Fasta
	H929DIANN.zip	Other
	H929raw.zip	Other
	Human_SwissProt_42375_20220921.fasta	Fasta
	K562data24h.zip	Other

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Publications

Proteomic Analysis Reveals Trilaciclib-Induced Senescence.

Hermosilla-Trespaderne Marina M Hu-Yang Mark Xinchen MX Dannoura Abeer A Frey Andrew M AM George Amy L AL Trost Matthias M Marín-Rubio José Luis JL

Molecular & cellular proteomics : MCP 20240426 6

Trilaciclib, a cyclin-dependent kinase 4/6 inhibitor, was approved as a myeloprotective agent for protecting bone marrow from chemotherapy-induced damage in extensive-stage small cell lung cancer. This is achieved through the induction of a temporary halt in the cell cycle of bone marrow cells. While it has been studied in various cancer types, its potential in hematological cancers remains unexplored. This research aimed to investigate the efficacy of trilaciclib in hematological cancers. Utili ...[more]

PMID: 38679389

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