Dataset Information
Proteins that interact with WDR1 following gambogic amide treatment
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Brain Cancer
SUBMITTER: 
Wei Han
LAB HEAD: Wei Han
PROVIDER: PXD045343 | Pride | 2024-01-26
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| checksum.txt | Txt | |||
| originaldata.rar | Other | |||
| search.rar | Other |
Items per page: 1 - 3 of 3 |
Publications
The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling.
Signal transduction and targeted therapy 20231108 1
Glioma is the most prevalent brain tumor, presenting with limited treatment options, while patients with malignant glioma and glioblastoma (GBM) have poor prognoses. The physical obstacle to drug delivery imposed by the blood‒brain barrier (BBB) and glioma stem cells (GSCs), which are widely recognized as crucial elements contributing to the unsatisfactory clinical outcomes. In this study, we found a small molecule, gambogic amide (GA-amide), exhibited the ability to effectively penetrate the bl ...[more]
