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Identification of mouse FcRn-specific vesicles in wild type and FcRn knockout podocytes

ABSTRACT: mouse podocytes overexpressing FcRn splice variants 1-5 were used to isolated FcRn-specific vesicles to identify the contents of those vesicles that are different from Rab5, 7, & 11 vesicles

INSTRUMENT(S): autoflex

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: George Haddad

LAB HEAD: Judith Blaine

PROVIDER: PXD045572 | Pride | 2024-05-24

REPOSITORIES: Pride

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			Action	DRS
	20230814_SCP_GeorgeHaddad_Fr1_Slot1-14_1_4825.pepXML	Pepxml
	20230814_SCP_GeorgeHaddad_Fr1_Slot1-14_1_4825_uncalibrated.mzML	Mzml
	20230814_SCP_GeorgeHaddad_Fr2_Slot1-15_1_4826.pepXML	Pepxml
	20230814_SCP_GeorgeHaddad_Fr2_Slot1-15_1_4826_uncalibrated.mzML	Mzml
	20230814_SCP_GeorgeHaddad_Fr3_Slot1-16_1_4827.pepXML	Pepxml

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Publications

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.

Haddad George G Blaine Judith J

Cells 20240329 7

Research into the neonatal Fc receptor (FcRn) has increased dramatically ever since Simister and Mostov first purified a rat version of the receptor. Over the years, FcRn has been shown to function not only as a receptor that transfers immunity from mother to fetus but also performs an array of different functions that include transport and recycling of immunoglobulins and albumin in the adult. Due to its important cellular roles, several clinical trials have been designed to either inhibit/enha ...[more]

PMID: 38607033

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