Proteomics

Dataset Information

0

LC-MS/MS analysis on in-vivo mice gastrointestinal digests


ABSTRACT: Food protein amyloid fibrils have superior technological,nutritional,sensorial,and physical properties compared to native monomers, butthere is yet insufficient understanding of their digestive fate and safety for wide consumption.By combining SDS,ELISA,fluorenscence,AFM, MALDI-MS, CD microfluidics,and SAXS techniques for the characterization of blg and lysozyme amyloid fibrils subjected to in-vitro gastrointestinal digestion.LC-MS/MS analysis on the fate of blg/lysozyme amyloid fibrils digested in vivo by mice was applied to verify our in vitro results.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Serum, Intestinal Juice, Colon

SUBMITTER: Dan Xu  

LAB HEAD: Raffaele Mezzenga

PROVIDER: PXD045698 | Pride | 2023-10-30

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
colon_blg_fibril_1.raw Raw
colon_blg_fibril_2.raw Raw
colon_blg_fibril_3.raw Raw
colon_blg_fibril_4.raw Raw
colon_blg_fibril_5.raw Raw
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Publications

Food amyloid fibrils are safe nutrition ingredients based on in-vitro and in-vivo assessment.

Xu Dan D   Zhou Jiangtao J   Soon Wei Long WL   Kutzli Ines I   Molière Adrian A   Diedrich Sabine S   Radiom Milad M   Handschin Stephan S   Li Bing B   Li Lin L   Sturla Shana J SJ   Ewald Collin Y CY   Mezzenga Raffaele R  

Nature communications 20231026 1


Food protein amyloid fibrils have superior technological, nutritional, sensorial, and physical properties compared to native monomers, but there is as yet insufficient understanding of their digestive fate and safety for wide consumption. By combining SDS-PAGE, ELISA, fluorescence, AFM, MALDI-MS, CD, microfluidics, and SAXS techniques for the characterization of β-lactoglobulin and lysozyme amyloid fibrils subjected to in-vitro gastrointestinal digestion, here we show that either no noticeable c  ...[more]

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