Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Jens Andersen
LAB HEAD: Jens S. Andersen
PROVIDER: PXD045842 | Pride | 2024-01-26
REPOSITORIES: Pride
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Polák Patrik P Garland William W Rathore Om O Schmid Manfred M Salerno-Kochan Anna A Jakobsen Lis L Gockert Maria M Gerlach Piotr P Silla Toomas T Andersen Jens S JS Conti Elena E Jensen Torben Heick TH
Cell reports 20231026 11
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the nuclear exosome targeting (NEXT) complex and the poly(A) exosome targeting (PAXT) connection. Via its association with the ARS2 and ZC3H18 proteins, NEXT/exosome is recruited to capped and short unadenylated transcripts. Conversely, PAXT/exosome is considered to target longer and adenylated substrates via their poly(A) tails. Here, mutational analysis of the core PAXT component ...[more]