Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Gediminas Plakys
LAB HEAD: Rolandas Meškys
PROVIDER: PXD045918 | Pride | 2024-01-26
REPOSITORIES: Pride
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HCT116_YqfB_Ni-NTA_10ul.raw.zip | Raw | |||
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Preitakaitė Viktorija V Barasa Povilas P Aučynaitė Agota A Plakys Gediminas G Koplūnaitė Martyna M Zubavičiūtė Simona S Meškys Rolandas R
PloS one 20231130 11
Gene-directed enzyme prodrug therapy is an emerging strategy for cancer treatment based on the delivery of a gene that encodes an enzyme that is able to convert a prodrug into a potent cytotoxin exclusively in target cancer cells. However, it is limited by the lack of suitable enzyme variants and a scarce choice of chemical bonds that could be activated. Therefore, this study is aimed to determine the capability of bacterial amidohydrolases YqfB and D8_RL to activate novel prodrugs and the effec ...[more]