Proteomics

Dataset Information

0

New orphan disease therapies from the proteome of industrial plasma processing waste


ABSTRACT: Plasma-derived therapeutic proteins are produced through an industrial fractionation process where proteins are purified from individual intermediates, some of which remain unused and are discarded. Relatively few plasma-derived proteins are exploited clinically, with most of available plasma being directed towards the manufacture of immunoglobulin and albumin. Although the plasma proteome provides opportunities to develop novel protein replacement therapies, particularly for rare diseases, the high cost of plasma together with small patient populations impact negatively on the development of plasma-derived orphan drugs. Enabling therapeutics development from unused plasma fractionation intermediates would therefore constitute a significant innovation. To this objective, we characterized the proteome of unused plasma fractionation intermediates and prioritized proteins for their potential as new candidate therapies for human disease.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Vittoria Cicaloni  

LAB HEAD: Laura Salvini

PROVIDER: PXD046234 | Pride | 2024-01-23

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
FASP_frazione_I_1.msf Msf
FIII_1.raw Raw
FIII_2.raw Raw
FIII_3.raw Raw
FIV1-4_1_1.raw Raw
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