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Longitudinal serum proteomics of mother-infant dyads with HLA-conferred type 1 diabetes risk

ABSTRACT: LC-MS/MS analysis formula was performed for sera from 22 mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes that were weaned to either an extensively hydrolyzed or regular infant milk. The samples included three samples from each mother (at the beginning of third trimester, at the time of delivery and 3 months postpartum) and five samples from each child (cord blood, 3, 6, 9 and 12 months). Targeted proteomics was used to validate differences observed between the feeding groups.Correlations in protein intensities within the dyads were detected together with perinatal and age-related changes.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Type 1 Diabetes Mellitus

SUBMITTER: Robert Moulder

LAB HEAD: Riitta Lahesmaa

PROVIDER: PXD046387 | Pride | 2024-05-27

REPOSITORIES: Pride

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			Action	DRS
	180904_1D_Lib_Test_Rep1.raw	Raw
	180905_Lib_10R_1.raw	Raw
	180905_Lib_10R_2.raw	Raw
	180905_Lib_2E_1.raw	Raw
	180905_Lib_2E_2.raw	Raw

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Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk

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