Dataset Information

Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients

ABSTRACT: • Project description: Why only half of the idiopathic peripheral polyneuropathy (IPN) patients develop neuropathic pain is unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain. We conducted unbiased mass-spectrometry proteomics analysis on blood plasma from 31 IPN patients with severe neuropathic pain and 29 IPN patients with no pain, to investigate protein biomarkers and protein-protein interactions associated with neuropathic pain. Univariate modeling was done with Linear mixed modeling (LMM) and corrected for multiple testing. Multivariate modelling was performed using elastic net analysis and validated with internal cross validation and bootstrapping.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Perry van Doormaal

LAB HEAD: Ahmet Hoke

PROVIDER: PXD046464 | Pride | 2025-02-19

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	LD_CS_LI-200219_HokeA_HA_V1.msf	Msf
	LD_CS_LI-200219_HokeA_HA_V1_F1.raw	Raw
	LD_CS_LI-200219_HokeA_HA_V1_F10.raw	Raw
	LD_CS_LI-200219_HokeA_HA_V1_F11.raw	Raw
	LD_CS_LI-200219_HokeA_HA_V1_F12.raw	Raw

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Publications

Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients.

van Doormaal Perry T C PTC Thomas Simone S Ajroud-Driss Senda S Cole Robert N RN DeVine Lauren R LR Dimachkie Mazen M MM Geisler Stefanie S Freeman Roy R Simpson David M DM Singleton J Robinson JR Smith A Gordon AG Stino Amro A Höke Ahmet A

Journal of the peripheral nervous system : JPNS 20231201 1

<h4>Background and aims</h4>Why only half of the idiopathic peripheral neuropathy (IPN) patients develop neuropathic pain remains unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain.<h4>Methods</h4>We conducted unbiased mass-spectrometry proteomics analysis on blood plasma from 31 IPN patients with severe neuropathic pain and 29 IPN patients with no pain, to investigate protein biomarkers and prote ...[more]

PMID: 37989721

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