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The interaction between DNMT3A with H3Kc36me2 modified nucleosomes

ABSTRACT: DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns, essential for the dynamic organization of vertebrate genomes. However, the mechanisms underlying DNMT3A1's recruitment and function within different chromatin environments remain unclear. We find that DNMT3A interacts with modified nucleosomes through multivalent interactions, involving both direct binding to chromatin features and site-specific post-translational histone modifications.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Juan Zou

LAB HEAD: Juri Rappsilber

PROVIDER: PXD046529 | Pride | 2024-12-07

REPOSITORIES: pride

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			Action	DRS
	Nucleosome_DNMT3A.fasta	Fasta
	Zou_Rappsilber_MW_DNMT3A_EDC_R1.mgf	Mgf
	Zou_Rappsilber_MW_DNMT3A_EDC_R1.raw	Raw
	Zou_Rappsilber_MW_DNMT3A_EDC_R1_Links.xlsx	Xlsx
	Zou_Rappsilber_MW_DNMT3A_EDC_R2.mgf	Mgf

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