Proteomics

Dataset Information

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Analysis of conformational changes induced by binding of allosteric nanobodies to a bacterial LRRK2 homologue by CX-MS


ABSTRACT: As part of an in-depth characterization of nanobodies directed against the Chlorobium tepidum protein CtRoco, a bacterial LRRK2 homologue, chemical crosslinking combined with mass spectrometry (CX-MS) was performed. Two allosteric nanobodies binding to two different epitopes in the LRR and the Roc domain of CtRoco, respectively were analysed using the CID-cleavable crosslinker disuccinimidyl sulfoxide (DSSO).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Chlorobium Tepidum

SUBMITTER: Christian Johannes Gloeckner  

LAB HEAD: Christian Johannes Gloeckner

PROVIDER: PXD046634 | Pride | 2024-04-23

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CtRoco-GTPgS-Nb1.mzML Mzml
CtRoco-GTPgS-Nb1.mzid.gz Mzid
CtRoco-GTPgS-Nb1_Nb2.mzML Mzml
CtRoco-GTPgS-Nb1_Nb2.mzid.gz Mzid
CtRoco-GTPgS-Nb2.mzML Mzml
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