B-Cell-based Therapy Controls Glioblastoma Growth by Producing Antibodies that Inhibit Tumor Invasion and Migration

ABSTRACT: Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor with limited therapeutic options and poor prognosis. Despite current treatments, the invasive nature of GBM often leads to recurrence. A promising alternative strategy is to harness the immune system's potential against tumor cells. Our previous data showed a B-cell-based vaccine, BVax, can provide a promising therapeutic potential for GBM. In this study, we aim to characterize the antigenic reactivity of BVax-derived antibodies and evaluate their therapeutic potential. We performed immunoproteomics and functional assays in murine models and human GBM patient samples.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Brain, B Cell

DISEASE(S): Brain Cancer

SUBMITTER: Si Wang  

LAB HEAD: Ctalina Lee-Chang

PROVIDER: PXD046712 | Pride | 2024-09-10

REPOSITORIES: Pride