Dataset Information

Ablation of integrin-mediated cell–collagen communication alleviates fibrosis

ABSTRACT: Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce biochemical and mechanical signals enabling cells to mount appropriate responses according to biological demands. The aim of this work was to investigate the in vivo role of collagen–fibroblast interactions for regulating fibroblast functions and fibrosis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skin

SUBMITTER: Ilian Atanassov

LAB HEAD: Prof. Dr. Thomas Krieg

PROVIDER: PXD046778 | Pride | 2023-11-08

REPOSITORIES: Pride

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Ablation of integrin-mediated cell-collagen communication alleviates fibrosis.

Sawant Mugdha M Wang Fang F Koester Janis J Niehoff Anja A Nava Michele M MM Lundgren-Akerlund Evy E Gullberg Donald D Leitinger Birgit B Wickström Sara S Eckes Beate B Krieg Thomas T

Annals of the rheumatic diseases 20230721 11

<h4>Objectives</h4>Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce biochemical and mechanical signals enabling cells to mount appropriate responses according to biological demands. The aim of this work was to investigate the in vivo role of collagen-fibroblast interactions for regulating fibroblast functions and fibrosis.<h4>M ...[more]

PMID: 37479494

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