Proteomics

Dataset Information

0

Extracellular matrix remodeling enhancing astrocyte lysosome pathway to reverse memory defected in Alzheimer’s disease


ABSTRACT: Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer’s disease (AD) risk, but its functions are not fully understood. Here, we found that medial prefrontal cortex (mPFC) injection with chondroitinase ABC (ChABC) to remodel ECM reverses short-term memory loss and reduces Aβ deposition in 5xFAD mice. ECM remodeling also reactivates astrocytes, untangles aggrecan’s entanglement with amyloid-beta (Aβ) plaques, and encourages astrocyte recruitment to the surrounding plaques. ECM remodeling promotes astrocyte phagocytosis of Aβ plaque by activating the astrocyte phagocytosis receptor mertk and astrocytic vesicle circulation. Importantly, ECM remodeling enhances the autophagy-lysosome pathway in astrocytes to mediate Aβ clearance and alleviate AD pathology. Our work thus discovers a cellular mechanism to remodel the ECM to active astrocyte autophagic lysosomal pathway alleviation AD pathology. It may represent a potential therapeutic strategy and serve as a hallmark for treating AD.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Qinghu Yang  

LAB HEAD: Zhantao Bai

PROVIDER: PXD046784 | Pride | 2024-10-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HFX6_FFRA22H000826-1A.raw Raw
HFX6_FFRA22H000827-1A.raw Raw
HFX6_FFRA22H000828-1A.raw Raw
HFX6_FFRA22H000829-1A.raw Raw
HFX6_FFRA22H000830-1A.raw Raw
Items per page:
1 - 5 of 22
altmetric image

Publications

Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy-Lysosome Pathway.

Yang Qinghu Q   Yan Chengxiang C   Sun Yahan Y   Xie Zhen Z   Yang Liang L   Jiang Ming M   Ni Junjun J   Chen Beining B   Xu Sen S   Yuan Zhaoyue Z   Wu Yanyan Y   Liu Xia X   Yuan Zengqiang Z   Bai Zhantao Z  

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20240617 31


Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer's disease (AD) risk; however, the underlying mechanisms are not fully understood. Here, it is found that the injection of chondroitinase ABC (ChABC), mimicking ECM remodeling, into the medial prefrontal cortex (mPFC) reversed short-term memory loss and reduced amyloid-beta (Aβ) deposition in 5xFAD mice. ECM remodeling also reactivated astrocytes, reduced the levels of aggrecan in Aβ plaques, and enhanced astrocyte recruitment  ...[more]

Similar Datasets

2023-03-14 | GSE227063 | GEO
2021-03-25 | PXD014274 | Pride
2024-06-30 | GSE267554 | GEO
2023-05-03 | GSE193513 | GEO
2022-10-10 | GSE195518 | GEO
2022-10-10 | GSE210257 | GEO
2021-06-02 | GSE163289 | GEO
2019-04-23 | GSE127892 | GEO
2019-04-23 | GSE127884 | GEO
2017-08-15 | GSE98563 | GEO