Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hek-293f Cell
SUBMITTER: Remigiusz Serwa
LAB HEAD: Jacek Jemielity
PROVIDER: PXD046838 | Pride | 2024-03-08
REPOSITORIES: Pride
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Warminski Marcin M Trepkowska Edyta E Smietanski Miroslaw M Sikorski Pawel J PJ Baranowski Marek R MR Bednarczyk Marcelina M Kedzierska Hanna H Majewski Bartosz B Mamot Adam A Papiernik Diana D Popielec Agnieszka A Serwa Remigiusz A RA Shimanski Brittany A BA Sklepkiewicz Piotr P Sklucka Marta M Sokolowska Olga O Spiewla Tomasz T Toczydlowska-Socha Diana D Warminska Zofia Z Wolosewicz Karol K Zuberek Joanna J Mugridge Jeffrey S JS Nowis Dominika D Golab Jakub J Jemielity Jacek J Kowalska Joanna J
Journal of the American Chemical Society 20240305 12
Eukaryotic mRNAs undergo cotranscriptional 5'-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as <sup>m6</sup>A<sub>m</sub>─a common epitranscriptomic mark unique to the mRNA 5'-end. This modification is regulated by the Pcif1 methyltransferase and the FTO demethylase, but its biological function is still unknown. Here, we designed and synthesized a trinucleotide FTO-resistant <i>N</i>6-benzyl analogue of the <sup>m6</sup>A<sub>m ...[more]