Proteomics

Dataset Information

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Candida auris proteomic profiling


ABSTRACT: In this study, we designed a novel antifungal agent, PQA-Az-13 that demonstrated antifungal activity against C. auris biofilms. Cellular proteomics indicated that PQA-Az-13 partially or completely inhibited numerous enzymatic proteins in C. auris biofilms, particularly those involved in both amino acid biosynthesis and metabolism processes, as well as in general energy-producing processes. Due to its hydrophobic nature and limited aqueous solubility, PQA-Az-13 was encapsulated in cationic liposomes and characterized by biophysical and spectral techniques. PQA-Az-13 liposomes demonstrated enhanced antifungal activity levels against both C. auris in in vitro biofilms and ex vivo skin colonization models.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): [candida] Auris

TISSUE(S): Biofilm, Cell Line Cell

SUBMITTER: Greg Sabat  

LAB HEAD: David Andes

PROVIDER: PXD046911 | Pride | 2023-12-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
10-Candida-lysate_Andes.mgf Mgf
10-Candida-lysate_Andes.mzid.gz Mzid
10-Candida-lysate_Andes.raw Raw
11-Candida-lysate_Andes.mgf Mgf
11-Candida-lysate_Andes.mzid.gz Mzid
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