Candida auris proteomic profiling
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ABSTRACT: In this study, we designed a novel antifungal agent, PQA-Az-13 that demonstrated antifungal activity against C. auris biofilms. Cellular proteomics indicated that PQA-Az-13 partially or completely inhibited numerous enzymatic proteins in C. auris biofilms, particularly those involved in both amino acid biosynthesis and metabolism processes, as well as in general energy-producing processes. Due to its hydrophobic nature and limited aqueous solubility, PQA-Az-13 was encapsulated in cationic liposomes and characterized by biophysical and spectral techniques. PQA-Az-13 liposomes demonstrated enhanced antifungal activity levels against both C. auris in in vitro biofilms and ex vivo skin colonization models.
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): [candida] Auris
TISSUE(S): Biofilm, Cell Line Cell
SUBMITTER: Greg Sabat
LAB HEAD: David Andes
PROVIDER: PXD046911 | Pride | 2023-12-07
REPOSITORIES: Pride
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