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Comprehensive PTP and proteome profiling from human liver tissues

ABSTRACT: The extent to which PTP (Protein tyrosine phosphatase) expression may be evident and contribute to the progression to non-alcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic liver disease (MASLD) in obesity and the development of hepatocellular carcinoma (HCC) remains unknown. We conducted a comprehensive analysis of the total proteome and PTP expression patterns, using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of human liver samples. The cohort included liver biopsies obtained from individuals presenting varying degrees of liver disease, encompassing steatosis, Non-alcoholic steatohepatitis (NASH), HCC, and control samples from individuals without evidence of liver damage.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Ziliang Ma

LAB HEAD: Wei Wu

PROVIDER: PXD046940 | Pride | 2024-09-24

REPOSITORIES: Pride

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			Action	DRS
	20190531_OR14_Ag2_Bauza001_SA_C-NASH_Proteome_H14.raw	Raw
	20190531_OR14_Ag2_Bauza001_SA_C-NASH_Proteome_H15.raw	Raw
	20190531_OR14_Ag2_Bauza001_SA_C-NASH_Proteome_H16.raw	Raw
	20190531_OR14_Ag2_Bauza001_SA_C-NASH_Proteome_H17.raw	Raw
	20190531_OR14_Ag2_Bauza001_SA_C-NASH_Proteome_H18.raw	Raw

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