Proteomics

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Proteomic analysis of JF-305 derivative CPEB1 knockdown/overexpression cells

ABSTRACT: Pancreatic cancer is a leading cause of cancer death worldwide. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is a fundamental translation regulatory factor regulating the polyadenylation process of messenger RNA. However, its biological functions in pancreatic cancer are poorly understood. Here the CPEB1 gene was knocked down or overexpressed in JF-305 cell line. To investigate the role of CPEB1 and new interacting proteins, proteomic analysis was performed using LC-MS/MS approach.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Jingnan Huang  

LAB HEAD: Changzheng Du

PROVIDER: PXD047241 | Pride | 2024-07-03

REPOSITORIES: Pride

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Dataset's files

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20230120_HPY_JF305_CPEB1.pg_matrix.xlsx Xlsx
20230120_HPY_JF305_CPEB1_1_R1.raw Raw
20230120_HPY_JF305_CPEB1_1_R1.raw.quant Raw
20230120_HPY_JF305_CPEB1_1_R2.raw Raw
20230120_HPY_JF305_CPEB1_1_R2.raw.quant Raw
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Publications

Pancreatic cancer is the deadliest malignancy with a poor response to chemotherapy but is potentially indicated for ferroptosis therapy. Here we identified that cytoplasmic polyadenylation element binding protein 1 (CPEB1) regulates NRF2 proteostasis and susceptibility to ferroptosis in pancreatic ductal adenocarcinoma (PDAC). We found that CPEB1 deficiency in cancer cells promotes the translation of p62/SQSTM1 by facilitating mRNA polyadenylation. Consequently, upregulated p62 enhances NRF2 sta  ...[more]

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