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Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

ABSTRACT: This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Keith Ray

LAB HEAD: Timothy J. Jarome

PROVIDER: PXD047293 | Pride | 2024-08-01

REPOSITORIES: Pride

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			Action	DRS
	230517_Jarome3_A1_01.mgf	Mgf
	230517_Jarome3_A1_01.msf	Msf
	230517_Jarome3_A1_01.msfView	Msf
	230517_Jarome3_A1_01.mzData	Other
	230517_Jarome3_A1_01.mzML	Mzml

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Publications

Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus.

Patrick Morgan B MB Preveza Natalie J NJ Kincaid Shannon E SE Setenet Gueladouan G Abraham Jennifer R JR Cummings Adam A Banani Shifa S Ray W Keith WK Helm Richard F RF Trask Sydney S Jarome Timothy J TJ

Brain research bulletin 20240613

The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical fo ...[more]

PMID: 38879089

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Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

Project description:This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

2024-08-01 | PXD047292 | Pride

Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

Project description:This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

2024-08-01 | PXD047289 | Pride

Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

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Protein degradation targets in hippocampus of the aged brain following context exposure

Project description:Protein degradation targets in hippocampus of the aged brain following context exposure

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Transcription profiling by array of hippocampal regions CA1, CA3, and DG from aged, calorically restricted rats

Project description:Aging is associated with a decline in hippocampal mediated learning and memory, a process which can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioural tests to assess their hippocampal function. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction.

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Transcription profiling of rat hippocampus from young and aged rats with age-related spatial learning impairments

2007-11-06 | E-GEOD-3531 | biostudies-arrayexpress

Transcription profiling of rat dentate gyrus of the hippocampus from young and aged rats to identification of putative learning and memory genes following the Morris Water Maze

Project description:The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris water maze, when compared to young rats. Then we isolated messenger RNA from the dentate gyrus of the hippocampus of each animal to interrogate Affymetrix RAE 230A rat genome microarrays. Supervised statistical analysis of the different groups of aged animals recognized 85 genes (p<0.005) that were significantly different in the dentate gyrus of aged rats that had learned the Morris water maze (MWM) paradigm when compared to learning impaired and a number of controls for stress, exercise and non-spatial learning. In addition, statistical analysis of the microarray data that included young and aged rats identified 1129 genes (p<0.005) that were differentially expressed between aged and young rats independent of behavior, but due to aging alone. Experiment Overall Design: a total of 80 samples were analyzed including aged and young rats for aged versus young comparisons. One chip was interrogated per animal. Supervised analysis of aged rat data (aged unimpaired (HID U) versus controls : HID I, VIS, YOKE, SIT includes 39 samples (intermediate learners were not included in the analysis). Controls include cage controls, yoke controls (no platform), visible platform controls.

2008-06-13 | E-GEOD-4821 | biostudies-arrayexpress

Sex differences in the role of protein degradation in the hippocampus during memory formation

Project description:This project examined sex differences in the role of degradation-specific protein polyubiquitination in the hippocampus during context fear memory formation in male and female rats.

2021-06-28 | PXD026212 | Pride

Transcription profiling of rat CA3 region of the hippocampus following control task or spatial modelling task

Project description:A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a spatial learning protocol to engage a pattern separation function to encode new information. After background training, two groups of animals experienced the same new training in a novel environment, however only one group was provided spatial information and demonstrated spatial memory in a retention test. Global transcriptional analysis of the microdissected subregions of the hippocampus exposed a CA3 pattern that was sufficient to clearly segregate spatial learning animals from control. Individual gene and functional group analysis anchored these results to previous work in neural plasticity. From a multitude of expression changes, increases in camk2a, rasgrp1 and nlgn1 were confirmed by in situ hybridization. Furthermore, siRNA inhibition of nlgn1 within the CA3 subregion impaired spatial memory performance, pointing to mechanisms of synaptic remodeling as a basis for rapid encoding of new information in long-term memory. Experiment Overall Design: RNA samples from animals subjected to a spatial learning paradigm were compared to controls using Affymetirx RAE230a chips. An N of 7 was used in each of the two experimental conditions.

2008-06-18 | E-GEOD-11473 | biostudies-arrayexpress

Transcription profiling of rat hippocampus from animals subjected to a spatial learning profile

Project description:A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a spatial learning protocol to engage a pattern separation function to encode new information. After background training, two groups of animals experienced the same new training in a novel environment, however only one group was provided spatial information and demonstrated spatial memory in a retention test. Global transcriptional analysis of the microdissected subregions of the hippocampus exposed a CA3 pattern that was sufficient to clearly segregate spatial learning animals from control. Individual gene and functional group analysis anchored these results to previous work in neural plasticity. From a multitude of expression changes, increases in camk2a, rasgrp1 and nlgn1 were confirmed by in situ hybridization. Furthermore, siRNA inhibition of nlgn1 within the CA3 subregion impaired spatial memory performance, pointing to mechanisms of synaptic remodeling as a basis for rapid encoding of new information in long-term memory. Experiment Overall Design: RNA samples from animals subjected to a spatial learning paradigm were compared to controls using Affymetirx RAE230a chips. An N of 6 was used in each of the two experimental conditions.

2008-06-18 | E-GEOD-11474 | biostudies-arrayexpress

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