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Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

ABSTRACT: This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Keith Ray

LAB HEAD: Timothy J. Jarome

PROVIDER: PXD047293 | Pride | 2024-08-01

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	230517_Jarome3_A1_01.mgf	Mgf
	230517_Jarome3_A1_01.msf	Msf
	230517_Jarome3_A1_01.msfView	Msf
	230517_Jarome3_A1_01.mzData	Other
	230517_Jarome3_A1_01.mzML	Mzml

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Publications

Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus.

Patrick Morgan B MB Preveza Natalie J NJ Kincaid Shannon E SE Setenet Gueladouan G Abraham Jennifer R JR Cummings Adam A Banani Shifa S Ray W Keith WK Helm Richard F RF Trask Sydney S Jarome Timothy J TJ

Brain research bulletin 20240613

The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical fo ...[more]

PMID: 38879089

Similar Datasets

Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

Project description:This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

2024-08-01 | PXD047289 | Pride

Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

Project description:This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

2024-08-01 | PXD047292 | Pride

Protein degradation targets in hippocampus and retrosplenial cortex of the aged brain

Project description:This project examined changes in degradation-specific K48 polyubiquitination in the hippocampus across the lifespan and during memory formation in old age in rats.

2024-08-01 | PXD047288 | Pride

Protein degradation targets in hippocampus of the aged brain following context exposure

Project description:Protein degradation targets in hippocampus of the aged brain following context exposure

2024-08-01 | PXD051644 | Pride

K63 polyubiquitin targets in the hippocampus of male and female rats following contextual fear conditioning

Project description:This experiment examined K63 polyubiquitin protein targets in the male and female hippocampus after contextual fear conditioning. Samples were the CA1 region of the dorsal hippocampus collected from male and female Sprague-Dawley rats that were 8-9 weeks old. Samples were collected 1 hour after contextual fear conditioning (Trained) or from non-stimulated controls (Naïve).

2024-12-02 | PXD054726 | Pride

K63 polyubiquitin targets in the hippocampus of male and female rats following contextual fear conditioning

2024-12-02 | PXD054877 | Pride

Transcription profiling by array of hippocampal regions CA1, CA3, and DG from aged, calorically restricted rats

Project description:Aging is associated with a decline in hippocampal mediated learning and memory, a process which can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioural tests to assess their hippocampal function. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction.

2010-06-08 | E-GEOD-21681 | biostudies-arrayexpress

Transcription profiling of rat hippocampus from young and aged rats with age-related spatial learning impairments

2007-11-06 | E-GEOD-3531 | biostudies-arrayexpress

Transcription profiling of rat dentate gyrus of the hippocampus from young and aged rats to identification of putative learning and memory genes following the Morris Water Maze

Project description:The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris water maze, when compared to young rats. Then we isolated messenger RNA from the dentate gyrus of the hippocampus of each animal to interrogate Affymetrix RAE 230A rat genome microarrays. Supervised statistical analysis of the different groups of aged animals recognized 85 genes (p<0.005) that were significantly different in the dentate gyrus of aged rats that had learned the Morris water maze (MWM) paradigm when compared to learning impaired and a number of controls for stress, exercise and non-spatial learning. In addition, statistical analysis of the microarray data that included young and aged rats identified 1129 genes (p<0.005) that were differentially expressed between aged and young rats independent of behavior, but due to aging alone. Experiment Overall Design: a total of 80 samples were analyzed including aged and young rats for aged versus young comparisons. One chip was interrogated per animal. Supervised analysis of aged rat data (aged unimpaired (HID U) versus controls : HID I, VIS, YOKE, SIT includes 39 samples (intermediate learners were not included in the analysis). Controls include cage controls, yoke controls (no platform), visible platform controls.

2008-06-13 | E-GEOD-4821 | biostudies-arrayexpress

Sex differences in the role of protein degradation in the hippocampus during memory formation

Project description:This project examined sex differences in the role of degradation-specific protein polyubiquitination in the hippocampus during context fear memory formation in male and female rats.

2021-06-28 | PXD026212 | Pride

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