Dataset Information

A study of proteomics changes in the Drosophila renal tubules during ageing

ABSTRACT: A quantitative proteomics study to identify proteomics differences between male and female, young (7 day) and aged tubules (28 day)

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Kidney

SUBMITTER: Helen Weavers

LAB HEAD: Helen Weavers

PROVIDER: PXD047350 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications

Functional-metabolic coupling in distinct renal cell types coordinates organ-wide physiology and delays premature ageing.

Holcombe Jack J Weavers Helen H

Nature communications 20231218 1

Precise coupling between cellular physiology and metabolism is emerging as a vital relationship underpinning tissue health and longevity. Nevertheless, functional-metabolic coupling within heterogenous microenvironments in vivo remains poorly understood due to tissue complexity and metabolic plasticity. Here, we establish the Drosophila renal system as a paradigm for linking mechanistic analysis of metabolism, at single-cell resolution, to organ-wide physiology. Kidneys are amongst the most ener ...[more]

PMID: 38110414

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