Inhalation of ACE2-expressing lung spheroid cell exosomes provides prophylactic protection against SARS-CoV-2
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ABSTRACT: We demonstrated that lung spheroid cell derived exosomes (LSC-Exo) carry the parental cell’s ACE2 that are able to target lung, intercept SARS-CoV-2 entry, confer protection against SARS-CoV-2 infection. This LSC-Exo prophylaxis paradigm would not be limited by viral evolution, showing great potential for emerged SARS-CoV-2 variants, including those that are yet to emerge.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Epithelial Cell
DISEASE(S): Disease Free
SUBMITTER: Zhenzhen Wang
LAB HEAD: Zhenzhen Wang
PROVIDER: PXD047542 | Pride | 2024-01-13
REPOSITORIES: Pride
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