Proteomics

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Histone deacetylase inhibition mitigates fibrosis-driven disease progression in recessive dystrophic epidermolysis bullosa

ABSTRACT: To delineate sodium valproate (VPA) molecular effects underlying mitigation of skin fibrosis in RDEB mice, mass spectrometry-based expression proteomics was performed on protein extracts from back skin of 16 weeks-old VPA-treated RDEB mice, vehicle-treated RDEB mice and WT littermates.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skin

DISEASE(S): Recessive Dystrophic Epidermolysis Bullosa

SUBMITTER: Joern Dengjel  

LAB HEAD: Joern Dengjel

PROVIDER: PXD047998 | Pride | 2024-08-31

REPOSITORIES: Pride

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20220911_MS_CR_Col0125_reDig_CTR01.raw Raw
20220911_MS_CR_Col0125_reDig_CTR02.raw Raw
20220911_MS_CR_Col0125_reDig_CTR03.raw Raw
20220911_MS_CR_Col0125_reDig_CTR04.raw Raw
20220911_MS_CR_Col0125_reDig_CTR05.raw Raw
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Publications

<h4>Background</h4>Recessive dystrophic epidermolysis bullosa (RDEB) is a blistering disease caused by mutations in the gene encoding type VII collagen (C7). RDEB is associated with fibrosis, which is responsible for severe complications. The phenotypic variability observed in siblings with RDEB suggests that epigenetic modifications contribute to disease severity. Identifying epigenetic changes may help to uncover molecular mechanisms underlying RDEB pathogenesis and new therapeutic targets.<h4  ...[more]

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