Proteomics

Dataset Information

0

Human cholangiocarcinoma LC-MS/MS


ABSTRACT: The glycosylation landscape of Human cholangiocarcinoma (CCA), and how it affects CCA diagnosis and prognosis, has recently emerged as an appealing research field.In this study, we used chemical glycoproteomic analysis Click-iG for systematic profiling of intact glycopeptides in CCA and HIBEpiC cell lines.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Cholangiocarcinoma

SUBMITTER: xiangfeng Meng  

LAB HEAD: Xiangfeng Meng

PROVIDER: PXD048188 | Pride | 2024-06-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
21-284_LJL0628_sample-HIBE-PG-1.raw Raw
21-284_LJL0628_sample-HIBE-PG-2.raw Raw
21-284_LJL0628_sample-HIBE-PG-3.raw Raw
21-284_LJL0628_sample-HU-PG-1.raw Raw
21-284_LJL0628_sample-HU-PG-2.raw Raw
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Publications

<i>O</i>-GlcNAcylation Facilitates the Interaction between Keratin 18 and Isocitrate Dehydrogenases and Potentially Influencing Cholangiocarcinoma Progression.

Meng Xiangfeng X   Zhou Yue Y   Xu Lei L   Hu Limu L   Wang Changjiang C   Tian Xiao X   Zhang Xiang X   Hao Yi Y   Cheng Bo B   Ma Jing J   Wang Lei L   Liu Jialin J   Xie Ran R  

ACS central science 20240423 5


Glycosylation plays a pivotal role in the intricate landscape of human cholangiocarcinoma (CCA), actively participating in key pathophysiological processes driving tumor progression. Among the various glycosylation modifications, <i>O</i>-linked β-<i>N</i>-acetyl-glucosamine modification (<i>O</i>-GlcNAcylation) emerges as a dynamic regulator influencing diverse tumor-associated biological activities. In this study, we employed a state-of-the-art chemical proteomic approach to analyze intact gly  ...[more]

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