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Exaptation of an evolutionary constraint enables behavioural control over the composition of secreted venom in giant centipedes

ABSTRACT: Venoms are biochemical arsenals that have emerged in numerous animal lineages, where they have coevolved with morphological and behavioural traits for venom production and delivery. In centipedes, venom evolution is thought to be constrained by the morphological complexity of their venom glands due to physiological limitations on the number of toxins produced by their secretory cells. Here, we show that the uneven toxin expression that results from these limitations have enabled giant centipedes to regulate the composition of their secreted venom despite having morphologically undifferentiated venom glands. We show that this control is likely achieved by the complex neuronal networks that innervate each venom gland subunit and is facilitated by morphological adaptations that circumvent the physiological evolutionary constraints on venom production. Our results suggest behavioural control over venom composition may be an overlooked aspect of venom biology and provide an example of how exaptation can facilitate evolutionary innovation and novelty.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Scolopendra Morsitans

TISSUE(S): Venom

SUBMITTER: Vanessa Schendel

LAB HEAD: Eivind A.

PROVIDER: PXD048264 | Pride | 2024-08-29

REPOSITORIES: Pride

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			Action	DRS
	Depleted_glands_IDA_RAT_SmG_DV1.group	Other
	Depleted_glands_IDA_RAT_SmG_DV1.wiff	Wiff
	Depleted_glands_IDA_RAT_SmG_DV1.wiff.scan	Wiff
	Depleted_glands_IDA_RAT_SmG_DV1_PeptideSummary.txt	Txt
	Depleted_glands_IDA_RAT_SmG_DV1_ProteinSummary.txt	Txt

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