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Comparative proteomics analysis of decidua tissues in early recurrent pregnancy loss

ABSTRACT: The project aimed to determine proteomics changes in decidua from patients suffering from unexplained early recurrent pregnancy loss (RPL) compared to women undergoing elective abortions. Comparative proteomics analysis by label-free data-independent LC-MS/MS was performed on fresh frozen decidua tissues from 19 RPL patients and 10 controls. Samples from EPL patients were preselected to include only patients with 2 or more recurrent pregnancy losses (RPL), no previous live birth, gestational week from 6-10 weeks and excluded fetal chromosomal abnormalities. Control samples were from women without history of previous miscarriage, ectopic pregnancy or preterm delivery, with at least one live born child, at 6-10 gestational weeks and without fetal chromosomal abnormalities. Patients and controls had no significant differences regarding age (Median age RPL = 30; Median age Controls = 34; Mann–Whitney U-test p = 0.082). The mean gestational weak (GW) was 7.9±1.0 weeks in the RPL group and 8.3±1.2 weeks in the control group, without statistically significant difference between groups (Median GW RPL = 8; Median GW Controls = 8; Mann–Whitney U-test p = 0.361).

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Decidua

DISEASE(S): Miscarriage

SUBMITTER: Katarina Davalieva

LAB HEAD: Katarina Davalieva

PROVIDER: PXD048340 | Pride | 2024-06-12

REPOSITORIES: Pride

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			Action	DRS
	Cont_M10_UDMse_0_9ul_15062023.raw.zip	Raw
	Cont_M1_UDMse_0_7ul_14062023.raw.zip	Raw
	Cont_M2_UDMse_1_3ul_14062023.raw.zip	Raw
	Cont_M3_UDMse_0_8ul_14062023.raw.zip	Raw
	Cont_M4_UDMse_0_9ul_15062023.raw.zip	Raw

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