Proteomics

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Complexome profiling of human induced pluripotent stem cells cultured during normoxic versus hypoxic conditions

ABSTRACT: Human induced pluripotent stem cells (hiPSCs) have become an invaluable tool for studying molecular disease mechanisms on a human genetic background. They can be differentiated into different cell types, including cardiac myocytes. Here, we studied the remodeling of mitochondrial protein complexes of hiPSCs cultured under hypoxic versus normoxic conditions.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ilka Wittig  

LAB HEAD: Friederike Cuello

PROVIDER: PXD048535 | Pride | 2025-01-07

REPOSITORIES: pride

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Data_analysis.xlsx Xlsx
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MQ_txt_Output_files.zip Other
P23_042_hiPSC_Hypoxia_01.raw Raw
P23_042_hiPSC_Hypoxia_02.raw Raw
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Publications

Human induced pluripotent stem cells (hiPSCs) are an invaluable tool to study molecular mechanisms on a human background. Culturing stem cells at an oxygen level different from their microenvironmental niche impacts their viability. To understand this mechanistically, dermal skin fibroblasts of 52 probands were reprogrammed into hiPSCs, followed by either hyperoxic (20 % O<sub>2</sub>) or physioxic (5 % O<sub>2</sub>) culture and proteomic profiling. Analysis of chromosomal stability by Giemsa-b  ...[more]

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