Dataset Information

Proteome of cerebral thrombi retrieved in acute phase of stroke (ThrombiOMIC)

ABSTRACT: The proteome of cerebral thrombi from patients recanalized by mechanical thrombectomy in an acute phase of stroke was carried out to determine biomarkers of stroke radio-clinical outcomes for stroke physicians (clinical outcome and mortality at 3 months, intracranial hemorrhagic transformation, etc.). Proteome of cerebral thrombi was also used to elucidate stroke physiopathology (paradoxical effect of glucose in acute phase of stroke) and evaluate recanalization treatments (intravenous thrombolysis by rt-PA and/or thrombectomy efficiency). ThrombiOMIC database was incremented by proteomic analyses of cerebral thrombi successfully retrieved from all consecutive stroke patients (n=59) with large vessel occlusion treated by mechanical thrombectomy in acute phase between October 2018 and August 2019 in the intensive care stroke unit of the University Hospital of Nice (France).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Clot

DISEASE(S): Cerebrovascular Disease

SUBMITTER: Laurent SUISSA

LAB HEAD: SUISSA Laurent

PROVIDER: PXD048837 | Pride | 2024-01-28

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	090120THROMBUS_BAS_01.mzML	Mzml
	THROMBUS_Gel_130_to_40_KDa.mzML	Mzml
	THROMBUS_Gel_130_to_40_KDa.mzid.gz	Mzid
	THROMBUS_Gel_40_to_15_KDa.mzid.gz	Mzid
	THROMBUS_Gel_40_to_15_KDa_N_01.raw	Raw

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Publications

Combined Omic Analyzes of Cerebral Thrombi: A New Molecular Approach to Identify Cardioembolic Stroke Origin.

Suissa Laurent L Guigonis Jean-Marie JM Graslin Fanny F Robinet-Borgomano Emmanuelle E Chau Yves Y Sedat Jacques J Lindenthal Sabine S Pourcher Thierry T

Stroke 20210521 9

<h4>Background and purpose</h4>The diagnosis of cardioembolic stroke can be challenging for patient management in secondary stroke prevention, particularly in the case of covert paroxysmal atrial fibrillation. The molecular composition of a cerebral thrombus is related to its origin. Therefore, proteomic and metabolomic analyses of the retrieved thrombotic material should allow the identification of biomarkers or signatures to improve the etiological diagnosis of stroke.<h4>Methods</h4>In this p ...[more]

PMID: 34015939

Publication: 1/2

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