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Quantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.

ABSTRACT: We describe the proteomic composition of the secretome of fetal and adult hematopoietic progenitors during MLL-rearranged (MLLr) leukemia initiation as well as the pre-leukemic cells’ secretion response to the treatment with Fibulin (Fbln1) and/or Fibronectin (Fn1) using data-independent acquisition mass spectrometry analysis.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Cell

SUBMITTER: Sudip Ghosh

LAB HEAD: Dr. Jenny Hansson

PROVIDER: PXD049014 | Pride | 2024-04-02

REPOSITORIES: Pride

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			Action	DRS
	20231123_PVA_allmedia_FL_SN18.sne	Other
	20231125_PVA_Media_BM_SN18.sne	Other
	20231207_2_PVA_Secretome_BM_FF_SN18_witoutoutliers.sne	Other
	20231208_2_PVA_Secretome_BM_D_withoutoutliers.sne	Other
	20231208_2_PVA_Secretome_FL_D_wihoutDOX5Ctrl1_SN18.sne	Other

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1 - 5 of 122

Publications

A complex interplay of intra- and extracellular factors regulates the outcome of fetal- and adult-derived MLL-rearranged leukemia.

Jassinskaja Maria M Ghosh Sudip S Watral Joanna J Davoudi Mina M Claesson Stern Melina M Daher Ugarit U Eldeeb Mohamed M Zhang Qinyu Q Bryder David D Hansson Jenny J

Leukemia 20240330 5

Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero-initiated and adult-onset MLLr leukemia. We reveal that fetal MLL::ENL-expressing lymphomyeloid multipotent progenitors (LMPPs) are intrinsically programmed towards a lymphoid fate but give rise to myeloid leukemia in vivo, highlighting a complex interplay of intra- and extracellular factors in determining disease subtype. W ...[more]

PMID: 38555405

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