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Unbiased Proteomic Profiling of Mouse Liver Tissue Samples Using HRM™ Mass Spectrometry

ABSTRACT: Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells

INSTRUMENT(S): 6110 Quadrupole LC/MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Malika Gantier

LAB HEAD: Tuan Huy

PROVIDER: PXD049134 | Pride | 2024-05-22

REPOSITORIES: Pride

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			Action	DRS
	J_D220525_MDIA_P2887_SExp01-BID001_R01.raw	Raw
	J_D220525_MDIA_P2887_SExp01-BID002_R01.raw	Raw
	J_D220525_MDIA_P2887_SExp01-BID003_R01.raw	Raw
	J_D220525_MDIA_P2887_SExp01-BID004_R01.raw	Raw
	J_D220525_MDIA_P2887_SExp01-BID005_R01.raw	Raw

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Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells.

Gantier Malika M Rispal Raphaël R Fourrier Angélique A Ménoret Séverine S Delbos Frédéric F Anegon Ignacio I Nguyen Tuan Huy TH

Stem cell research & therapy 20240312 1

<h4>Background</h4>Liver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor shortage. Hepatocyte transplantation emerged as a viable alternative to liver transplantation. Considering their unique expansion capabilities and their potency to be driven toward a chosen cell fate, pluripotent stem cells are extensively studied as an unlimited cell source of hepatocytes for cell therapy. It has been previously shown that fres ...[more]

PMID: 38475825

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