Dataset Information

Site-Specific Glycosylation Analysis of Murine and Human Fcɣ Receptors IIA and IIB.

ABSTRACT: Site-specific glycosylation analysis by nLC-MS/MS of recombinant human Fcγ receptors IIA (H&R167 isoforms), IIB and murine Fcγ receptor IIB.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

SUBMITTER: Carlos Pavan

LAB HEAD: Kevin Brown Chandler

PROVIDER: PXD049429 | Pride | 2024-08-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	2023-05-25-hFcgRIIA-H167-chymo-250ng-MSonly-A.raw	Raw
	2023-05-25-hFcgRIIA-H167-chymo-250ng-MSonly-B.raw	Raw
	2023-05-25-hFcgRIIA-H167-chymo-250ng-MSonly-C.raw	Raw
	2023-05-25-hFcgRIIA-H167-chymo-250ng-MSonly-D.raw	Raw
	2023-05-25-hFcgRIIA-H167-chymo-750ng-A.raw	Raw

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Publications

Site-Specific Glycosylation Analysis of Human and Murine Fcγ Receptor II Family Members Reveals Variant-Specific <i>N</i>-Glycosylation.

Abdoollah Zaraah Z Marrero Roche Daniel E DE Pavan Carlos H CH Moore Erika E Chandler Kevin Brown KB

Journal of proteome research 20240715 8

Fcγ-receptors (FcγRs) including FcγRII (CD32) gene family members are expressed on leukocytes, bind the crystallizable fragment (Fc) region of immunoglobulin G (IgG), and bridge humoral and cellular immunity. FcγRIIA and FcγRIIB have opposing roles, with the former responsible for activation and the latter for inhibition of immune cell signaling and effector functions. The extracellular domains of human and murine FcγRIIs share multiple conserved <i>N-</i>glycosylation sites. Understanding the r ...[more]

PMID: 39007905

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