Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney
SUBMITTER: Sarah Masser
LAB HEAD: Ulrich Stelzl
PROVIDER: PXD049436 | Pride | 2024-03-14
REPOSITORIES: Pride
Action | DRS | |||
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10_Plin1_77_un_BD2_1_9582.d.rar | Other | |||
10_Plin1_77_un_BD2_1_9606.d.rar | Other | |||
16_Plin5_77_un_BD8_1_9594.d.rar | Other | |||
16_Plin5_77_un_BD8_1_9598.d.rar | Other | |||
2_Plin1_77_ind_BC2_1_9564.d.rar | Other |
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Nature communications 20240321 1
ATGL is a key enzyme in intracellular lipolysis and plays an important role in metabolic and cardiovascular diseases. ATGL is tightly regulated by a known set of protein-protein interaction partners with activating or inhibiting functions in the control of lipolysis. Here, we use deep mutational protein interaction perturbation scanning and generate comprehensive profiles of single amino acid variants that affect the interactions of ATGL with its regulatory partners: CGI-58, G0S2, PLIN1, PLIN5 a ...[more]