Dataset Information

Fkbp5 Gene Deletion: Impacts on Circadian Rhythmicity and Brain Proteomics in Aged Mice

ABSTRACT: FKBP51, also known as FK506-binding protein 51, is a molecular chaperone and scaffolding protein with significant roles in regulating hormone signaling and stress responding. Genetic variants in FKBP5, which encodes FKBP51, have been implicated in a growing number of neuropsychiatric disorders, which has spurred efforts to target FKBP51 therapeutically. However, the molecular mechanisms by which FKBP51 influences the pathways affected in these disorders are not fully understood. Protein changes in Fkbp5 KO mice, as measured by histology and proteomics, revealed alterations in a brain region- and sex-dependent manner.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Stanley Stevens

LAB HEAD: Stanley Stevens

PROVIDER: PXD049439 | Pride | 2024-09-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Amyg_WTvKO_MvF_rerun.tsv	Tabular
	DIANN_LB_Niat_Hippo_M_F_results_Rerun.tsv	Tabular
	LB_NG_Amyg_F18KO_1_DIA_90m_10th_3ul_Slot1-40_4-28-2023_5687.d.zip	Other
	LB_NG_Amyg_F18KO_2_DIA_90m_10th_3ul_Slot1-49_4-30-2023_5703.d.zip	Other
	LB_NG_Amyg_F18KO_3_DIA_90m_10th_3ul_Slot1-22_5-1-2023_5719.d.zip	Other

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Publications

Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice.

Gebru Niat T NT Guergues Jennifer J Verdina Laura A LA Wohlfahrt Jessica J Wang Shuai S Armendariz Debra S DS Gray Marsilla M Beaulieu-Abdelahad David D Stevens Stanley M SM Gulick Danielle D Blair Laura J LJ

Aging cell 20240903 12

FKBP51, also known as FK506-binding protein 51, is a molecular chaperone and scaffolding protein with significant roles in regulating hormone signaling and responding to stress. Genetic variants in FKBP5, which encodes FKBP51, have been implicated in a growing number of neuropsychiatric disorders, which has spurred efforts to target FKBP51 therapeutically. However, the molecular mechanisms and sub-anatomical regions influenced by FKBP51 in these disorders are not fully understood. In this study, ...[more]

PMID: 39225086

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