Proteomics

Dataset Information

0

Phosphoproteomics of Natural Killer (NK) Cells Stimulated with Fibrin and IL-15


ABSTRACT: Phosphoproteomic analysis of fibrin or IL-15 treated NK cells with timsTOF HT

INSTRUMENT(S): timsTOF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Mehdi Bouhaddou  

LAB HEAD: Mehdi Bouhaddou

PROVIDER: PXD049692 | Pride | 2024-06-26

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
20231023_090230_2023-10-21_KA1_PH.sne Other
20231023_090251_2023-10-21_KA1_PH_Report.tsv Tabular
Raw_files_description.xlsx Xlsx
TOF01641_2_1_1683.d.zip Other
TOF01642_2_1_1684.d.zip Other
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Publications

Fibrin drives thromboinflammation and neuropathology in COVID-19.

Ryu Jae Kyu JK   Yan Zhaoqi Z   Montano Mauricio M   Sozmen Elif G EG   Dixit Karuna K   Suryawanshi Rahul K RK   Matsui Yusuke Y   Helmy Ekram E   Kaushal Prashant P   Makanani Sara K SK   Deerinck Thomas J TJ   Meyer-Franke Anke A   Rios Coronado Pamela E PE   Trevino Troy N TN   Shin Min-Gyoung MG   Tognatta Reshmi R   Liu Yixin Y   Schuck Renaud R   Le Lucas L   Miyajima Hisao H   Mendiola Andrew S AS   Arun Nikhita N   Guo Brandon B   Taha Taha Y TY   Agrawal Ayushi A   MacDonald Eilidh E   Aries Oliver O   Yan Aaron A   Weaver Olivia O   Petersen Mark A MA   Meza Acevedo Rosa R   Alzamora Maria Del Pilar S MDPS   Thomas Reuben R   Traglia Michela M   Kouznetsova Valentina L VL   Tsigelny Igor F IF   Pico Alexander R AR   Red-Horse Kristy K   Ellisman Mark H MH   Krogan Nevan J NJ   Bouhaddou Mehdi M   Ott Melanie M   Greene Warner C WC   Akassoglou Katerina K  

Nature 20240828 8031


Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection<sup>1-4</sup>. Despite the clinical evidence<sup>1,5-7</sup>, the underlying mechanisms of coagulopathy in COVID-19 and its consequences in inflammation and neuropathology remain poorly understood and treatment options are insufficient. Fibrinogen, the central structural component of blood clots, is abundant  ...[more]

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