Dataset Information
Analysis of ZNF827 Halotag pulldown for a manuscript titled ‘ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway’
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Christopher Nelson
LAB HEAD: Hilda Pickett
PROVIDER: PXD050191 | Pride | 2024-06-23
REPOSITORIES: pride
Dataset's files
Items per page: 1 - 5 of 9 |
Publications
ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway.
Nature communications 20240312 1
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as a component of the ATR-CHK1 kinase pathway. We demonstrate that ZNF827 is a ssDNA binding protein that associates with RPA through concurrent binding to ssDNA intermediates. These interactions are dependent on two clusters of C2H2 zinc finger mo ...[more]
