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Cardiovascular symptoms of PASC are associated with trace-level circulatory cytokines that affect the function of primary human cardiomyocytes

ABSTRACT: Globally, over 65 million individuals are estimated to suffer from post-acute sequelae of COVID-19 (PASC). A large number of individuals living with PASC experience cardiovascular symptoms (i.e. chest pain and heart palpitations) (PASC-CVS). The role of chronic inflammation in these symptoms, in particular in individuals with symptoms persisting for >1 year after SARS-CoV-2 infection, remains to be determined. Here, we show that compared to individuals with a resolved SARS-CoV-2 infection (and no persistent symptoms), individuals with prolonged PASC-CVS had elevated levels of pro-inflammatory cytokines. However, these cytokines were found to be present in trace amounts, such that they could only be detected with the use of novel nanotechnology. Importantly, these trace-level cytokines had a direct effect on the functionality of primary human cardiomyocytes in vitro. Proteomics analyses demonstrated further differences in PASC-CVS and recovered plasma including increased abundance of complement and coagulation associated proteins.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Cardiovascular System Disease,Long Covid

SUBMITTER: Kyle Macauslane

LAB HEAD: Benjamin L Schulz

PROVIDER: PXD050202 | Pride | 2024-11-01

REPOSITORIES: Pride

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			Action	DRS
	20231206_Schulz_LCOVID_Plasma_002.wiff	Wiff
	20231206_Schulz_LCOVID_Plasma_002.wiff.scan	Wiff
	20231206_Schulz_LCOVID_Plasma_003.wiff	Wiff
	20231206_Schulz_LCOVID_Plasma_003.wiff.scan	Wiff
	20231206_Schulz_LCOVID_Plasma_004.wiff	Wiff

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