Proteomics

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Unraveling the Molecular Landscape of Lead-Induced Cochlear Synaptopathy: A Quantitative Proteomic Analysis

ABSTRACT: This study investigates how lead exposure triggers cochlear synaptopathy and hearing loss in mice. Young-adult CBA/J mice were given lead acetate in drinking water for 28 days. We assessed hearing thresholds, outer hair cell activity, and synaptic changes in the cochlea. Lead exposure raises hearing thresholds, indicating cochlear synaptopathy. Notably affects synapses in the basal turn without impacting outer hair cells. In addition to this, lead altered the abundance of 352 synaptic proteins, with the synaptic vesicle cycle pathway prominently affected. Lead-induced cochlear synaptopathy targets basal cochlear regions, implicating synaptic vesicle cycle signaling in hearing loss. Revealing specific mechanisms behind lead-induced hearing deficits enhances targeted interventions and preventive strategies, advancing our understanding of lead induced hearing loss.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cochlea

DISEASE(S): Sensorineural Hearing Loss

SUBMITTER: Pankaj Bhatia  

LAB HEAD: Samson Jamesdaniel, PhD

PROVIDER: PXD050415 | Pride | 2024-10-17

REPOSITORIES: Pride

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Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis.

Bhatia Pankaj P   Mehmood Shomaila S   Doyon-Reale Nicole N   Rosati Rita R   Stemmer Paul M PM   Jamesdaniel Samson S  

Frontiers in cellular neuroscience 20240722

<h4>Introduction</h4>Exposure to heavy metal lead can cause serious health effects such as developmental neurotoxicity in infants, cognitive impairment in children, and cardiovascular and nephrotoxic effects in adults. Hearing loss is one of the toxic effects induced by exposure to lead. Previous studies demonstrated that exposure to lead causes oxidative stress in the cochlea and disrupts ribbon synapses in the inner hair cells.<h4>Methods</h4>This study investigated the underlying mechanism by  ...[more]

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