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Rat thymus proteomics study of FNC 1

ABSTRACT: Thymus is the important immune organ, responsible for T cell development and differentiation.We conduct rat thymus proteomics study of FNC.

INSTRUMENT(S): time-of-flight

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Thymus

SUBMITTER: ning sheng

LAB HEAD: ning sheng

PROVIDER: PXD050620 | Pride | 2024-08-10

REPOSITORIES: Pride

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Publications

Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect.

Sheng Ning N Li Rui R Li Yang Y Wang Zhe Z Wang Lulu L Li Yuhuan Y Zhang Jinlan J Jiang Jiandong J

Acta pharmaceutica Sinica. B 20240330 7

Thymus is the important immune organ, responsible for T cell development and differentiation. The lower circulating T counts have been observed in patients who died from COVID-19 compared with survivors. Azvudine, also known as FNC, is a thymus-homing anti-SARS-CoV-2 drug in treating COVID-19 patients. In this study, single-cell transcriptome, proteomics, and parallel reaction monitoring (PRM) were applied to insight into the activation process of FNC in rat and SARS-CoV-2 rhesus monkey thymus. ...[more]

PMID: 39027259

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