Dataset Information
Rat thymus proteomics study of FNC 1
Ontology highlight
ABSTRACT:
INSTRUMENT(S): time-of-flight
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Thymus
SUBMITTER: 
ning sheng
LAB HEAD: ning sheng
PROVIDER: PXD050620 | Pride | 2024-08-10
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 1.raw | Raw | |||
| 10.raw | Raw | |||
| 1proteins.xlsx | Xlsx | |||
| 2.raw | Raw | |||
| 3.raw | Raw |
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Publications
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect.
Acta pharmaceutica Sinica. B 20240330 7
Thymus is the important immune organ, responsible for T cell development and differentiation. The lower circulating T counts have been observed in patients who died from COVID-19 compared with survivors. Azvudine, also known as FNC, is a thymus-homing anti-SARS-CoV-2 drug in treating COVID-19 patients. In this study, single-cell transcriptome, proteomics, and parallel reaction monitoring (PRM) were applied to insight into the activation process of FNC in rat and SARS-CoV-2 rhesus monkey thymus. ...[more]
