Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Escherichia Coli
SUBMITTER: Artem Isaev
LAB HEAD: Artem Isaev
PROVIDER: PXD050621 | Pride | 2024-06-23
REPOSITORIES: Pride
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pTn5053_1.raw | Raw | |||
pTn5053_2.raw | Raw | |||
pTn5053_3.raw | Raw | |||
pTn5053_delta_Chi_1.raw | Raw | |||
pTn5053_delta_Chi_2.raw | Raw |
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Nucleic acids research 20240501 9
Bacterial defence systems are tightly regulated to avoid autoimmunity. In Type I restriction-modification (R-M) systems, a specific mechanism called restriction alleviation (RA) controls the activity of the restriction module. In the case of the Escherichia coli Type I R-M system EcoKI, RA proceeds through ClpXP-mediated proteolysis of restriction complexes bound to non-methylated sites that appear after replication or reparation of host DNA. Here, we show that RA is also induced in the presence ...[more]