Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, Epithelial Cell
SUBMITTER: Greg Sabat
LAB HEAD: Dr. Richard A Anderson
PROVIDER: PXD050817 | Pride | 2024-10-17
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
F001836.dat | Other | |||
F001837.dat | Other | |||
F001838.dat | Other | |||
Mock_IP_AndersonR.MGF | Mgf | |||
Mock_IP_AndersonR.mzid.gz | Mzid |
Items per page: 5 1 - 5 of 13 |
Thapa Narendra N Chen Mo M Cryns Vincent L VL Anderson Richard R
Cell reports 20240416 5
Phosphatidylinositol 3-kinase α (PI3Kα) is a heterodimer of p110α catalytic and p85 adaptor subunits that is activated by agonist-stimulated receptor tyrosine kinases. Although p85α recruits p110α to activated receptors on membranes, p85α loss, which occurs commonly in cancer, paradoxically promotes agonist-stimulated PI3K/Akt signaling. p110α localizes to microtubules via microtubule-associated protein 4 (MAP4), facilitating its interaction with activated receptor kinases on endosomes to initia ...[more]