Dataset Information
Systematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Hengxing Chen
LAB HEAD: Hengxing Chen
PROVIDER: PXD050906 | Pride | 2024-05-09
REPOSITORIES: Pride
Dataset's files
Items per page: 1 - 5 of 8 |
Publications
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Nature 20240703 8021
The Warburg effect is a hallmark of cancer that refers to the preference of cancer cells to metabolize glucose anaerobically rather than aerobically<sup>1,2</sup>. This results in substantial accumulation of lacate, the end product of anaerobic glycolysis, in cancer cells<sup>3</sup>. However, how cancer metabolism affects chemotherapy response and DNA repair in general remains incompletely understood. Here we report that lactate-driven lactylation of NBS1 promotes homologous recombination (HR)- ...[more]
