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Identification and Quantification of Human Relaxin Proteins by Immunoaffinity-Mass Spectrometry

ABSTRACT: We developed immunoaffinity-selected reaction monitoring assays for the measurment of human relaxin-1 and relaxin-2 proteins in biological and clinical samples.

INSTRUMENT(S): Orbitrap Exploris 480, LTQ Orbitrap Elite, Q TRAP, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Andrei Drabovich

LAB HEAD: Andrei Drabovich

PROVIDER: PXD051230 | Pride | 2024-07-04

REPOSITORIES: Pride

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			Action	DRS
	E202403121-09-C1-LNCaP-AD1-RLN1.raw	Raw
	E202403121-10-E1-SeminalPool-5x-AD1-RLN1-1.raw	Raw
	E202403121-11-E1-SeminalPool-5x-AD1-RLN1-2_20240322145410.raw	Raw
	E202403121-12-D1-SeminalPool-3x-AD1-RLN1-1.raw	Raw
	E202403121-13-D1-SeminalPool-3x-AD1-RLN1-2.raw	Raw

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Publications

Identification and Quantification of Human Relaxin Proteins by Immunoaffinity-Mass Spectrometry.

Rais Yasmine Y Drabovich Andrei P AP

Journal of proteome research 20240513 6

The human relaxins belong to the Insulin/IGF/Relaxin superfamily of peptide hormones, and their physiological function is primarily associated with reproduction. In this study, we focused on a prostate tissue-specific relaxin RLN1 (REL1_HUMAN protein) and a broader tissue specificity RLN2 (REL2_HUMAN protein). Due to their structural similarity, REL1 and REL2 proteins were collectively named a 'human relaxin protein' in previous studies and were exclusively measured by immunoassays. We hypothesi ...[more]

PMID: 38739617

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